ABSTRACT
The novel corona virus infection had become a global epidemic due to its rapid spread. So, there is an urgent need to treat COVID-19 patients. The aim of this research was to hypothesize and examine vitamin drug conjugate as targeted moiety. The present scaffold may have potential role to fight against COVID-19 infection due to its antimicrobial, antioxidants and immunomodulatory activities. Here, we've highlighted the term Vitamin Drug Conjugate as possible therapy approach for SARS-COV-2 infection. As a result, we synthesize, characterized, and evaluated a Hydroxychloroquine — Folic Acid conjugate (HCQ-FA) by esterification mechanism to provide effective treatment against SARS-CoV-2 infection by enhancing therapeutic effect through synergistic mechanism, masking undesired side effects, and improving cellular internalization. By using prodrug, the efficacy and bioavailability of existing antiviral drugs could be improved. The structure of the conjugate was determined by spectroscopic data like IR, NMR, and mass spectra, which indicates that HCQ-FA conjugate formed by esteric conjugation. Molecular docking studies revealed that HCQ-FA conjugate shows good level of docking as well as binding interaction with main protease moiety. Molecular dynamic stimulation revealed that this conjugate shows good stability at the binding site of SARS main protease moiety and exhibits inhibitory activity against COVID-19 infection. © 2022 The Authors.
ABSTRACT
India being the most populous country had to tailor made its approaches to tackle the coronavirus disease 2019 (COVID-19) pandemic. Public health expenditure in India is just above 1% of gross domestic product. The warning signs of pandemic arrival in India were knocking our health-care system since the first few cases surfaced in Kerala. Social distancing as a method of keeping the virus at bay was first officially flagged by the Prime Minister Narendra Modi on March 19 in order to call for a 1-day “Janata Curfew” on March 22. The Epidemic Disease Act was implemented, and special task force was developed to draft guidelines for personal hygiene, surveillance, contact tracing, quarantine, diagnosis, laboratory tests, and the management of COVID-19. The Aarogya Setu app was developed to alert the public about COVID-19 symptoms, contact tracing, and the nearest contact of health-care center. We need to strive to extricate our country from this situation as advised by Krishna, “Uddharet Atmanatmanam—a person has to lift himself up;a man is his own best friend as also enemy.” © 2022 Elsevier Inc. All rights reserved.